Wexford Science & Technology and the University City Science Center sought to expand the uCity Square district with a high-performance building that supports research, innovation, and commercial activity. O Z Collaborative, in collaboration with ZGF, designed One uCity Square, a 14-story, 498,000-square-foot mixed-use tower that integrates laboratory, office, and ground-floor retail space. The building is organized to support flexible laboratory environments and adaptable office layouts, accommodating a range of tenants and evolving program needs. Ground-floor retail activates the street and contributes to the public realm.

A structured parking component provides 149 automobile spaces and 104 bicycle spaces, supporting multiple modes of access. Sustainability was central to the design, with the building achieving LEED Gold certification through strategies that enhance energy performance and occupant well-being. One uCity Square contributes to the continued growth of uCity Square as a hub for research, collaboration, and innovation in University City.